The Erdbrügger Lab is interested in studying the fascinating role of extracellular vesicles (EVs) as novel bio-markers and bio-activators in kidney disease and high blood pressure. EVs are a very heterogeneous group of small vesicles which can derive from all cells in the body either by secretion or blebbing of cell membranes. Inititally thought as “cell trash” EVs are emerging as novel communicators in health and disease. Because of their small size (submicron) and heterogeneous nature our second focus of research is optimization of EV isolation and characterization. See links to our publications for more details.

Latest Publications:

1. Bielopolski, …, Erdbrügger, U. Effect of the DASH diet on the sodium-chloride cotransport and aquaporin-2 in urinary extracellular vesicles. Am J Physol Renal Physiol. 2024 Apr.
2. Erdbrügger U, ..., Burger D. Extracellular Vesicles in Kidney Dieseases: Moving Forward. Kidney3600. 2023 Feb.
3. Erdbrügger U*, ..., Martens-Uzunova ES. Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. J Extracell Vesicles. 2021 May.
4. La Salvia S, ..., Erdbrügger U* (senior). T cell-derived extracellular vesicles are elevated in essential HTN. Am J Physiol Renal Physiol. 2020 Nov.
5. Musante L, ..., Erdbrügger U*. Rigorous characterization of urinary extracellular vesicles (uEVs) in the low centrifugation pellet – a neglected source for uEVs. Scientific report. 2020 Feb.
6. Good ME, ..., Erdbrügger U*. Circulating Extracellular Vesicles in Normotension Restrain Vasodilation in Resistatnce Arteries. Hypertension. 2020 Jan.

Full Publication List:

Dr. Uta Erdbrügger